A 36 yr old male has been suffering with what appears to be upper gastric pain f

Question

A 36 yr old male has been suffering with what appears to be upper gastric pain for approximately one month. One Sunday morning the pain is unbearable and he decides to go to the emergency room at the local hospital. He describes it as a rather sharp pain that lasts for two to three hours, and then it starts to resolve. He indicates that he has vomited three times, and often suffers from nausea intermittently. He also says that these bouts do not nessarily occur during or after eating. An ultrasound promptly discovers several gallstones within the gallbladder and several smaller ones that appear to be blocking his cystic duct. Which substance is readily responsible ygallbladder contraction? What initiating physiological event must precede the secretion of this substance? What could possibly be a consequence of not having this situation medically corrected? Does secretin have any role in this event? Why is enterogastrone not likely to be involved in this scenario?

Explanation / Answer

Cholecystokinin (CCK) is the major hormone responsible for gallbladder contraction.

CCK is released when partially digested food from the stomach reaches the first part of the small intestinal.

Gallbladder is responsible for the production and storage, and transport of bile. Bile is responsible for breakdown and digestion of fatty food in the small intestine. If this situation is left uncorrected, then the patient cannot digest fatty foods.

Yes, secretin also has a role in this event. Secretin is responsible for stimulating the pancreas to produce digestive fluids that are rich in bicarbonate and neutralizers. Secretin stimulates the pancreas to produce digestive juices that are stored in gallbladder.

Enterogastrone is not involved because this hormone is produced by the mucosa of the duodenum in the lower gastrointestinal tract.

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