What is the effect of the following changes on the oxygen affinity of hemoglobin

Question

What is the effect of the following changes on the oxygen affinity of hemoglobin? (a) a drop in pH of blood plasma from 7.4 to 7.2. (b) a decrease in the partial pressure of CO2 in lungs from 6kpa(holding ones breath) to 2kpa (normal)? (C) an increase in the BPG level from 5mM (normal altitude) to 8mM (high altitude). (d) an increase in CO from 1.0 ppm in a normal indoor atmosphere to 30ppm in home that has a malfunctioning or leaking furnace ? What is the effect of the following changes on the oxygen affinity of hemoglobin? (a) a drop in pH of blood plasma from 7.4 to 7.2. (b) a decrease in the partial pressure of CO2 in lungs from 6kpa(holding ones breath) to 2kpa (normal)? (C) an increase in the BPG level from 5mM (normal altitude) to 8mM (high altitude). (d) an increase in CO from 1.0 ppm in a normal indoor atmosphere to 30ppm in home that has a malfunctioning or leaking furnace ? (a) a drop in pH of blood plasma from 7.4 to 7.2. (b) a decrease in the partial pressure of CO2 in lungs from 6kpa(holding ones breath) to 2kpa (normal)? (C) an increase in the BPG level from 5mM (normal altitude) to 8mM (high altitude). (d) an increase in CO from 1.0 ppm in a normal indoor atmosphere to 30ppm in home that has a malfunctioning or leaking furnace ?

Explanation / Answer

Based on the given data,

The hemoglobin affinity towards it ligand oxygen is regulated on the BPG, CO2 and H+. Binding of these molecules to hemoglobin or presence of higher concentration than O2 reduces the affinity of hemoglobin for Oxygen. Therefore,   

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