1- Taxol treatment causes cells to arrest (get stuck) in the cell cycle. Which p
ID: 67407 • Letter: 1
Question
1- Taxol treatment causes cells to arrest (get stuck) in the cell cycle. Which phase of the cell cycle would the cells become arrested in and why?
2- However, sometimes cancer cells gain additional mutations that can override the taxol-induced arrest in the cell cycle and these cancer cells are then able to split sister chromatids and complete mitosis and cytokinesis in the ABSENCE of any microtubule function. This produces daughter cells with varying numbers of chromosomes instead of daughters with equal chromosome content. Explain why varying numbers of chromosomes are inherited in this situation.
Explanation / Answer
1. The cells will become arrested in the G1 phase of the mitotic cell cycle. It is mainly the spindle assembly checkpoint where the cells are stuck so that chromosomes are unable to segregate and cells fail to resume anaphase. Overall this blocks the cell cycle and may also result in apoptopic cell death.
2. The varying number of chromosomes are inherited in this situation because the cells which were able to override and complete mitosis were in tetraploid state. Though the cells in tetraploidy state are able to complete mitosis but they result in varying number of chromosomes.
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