These are questions from cell molecular biology , and it requires some extensive

Question

These are questions from cell molecular biology, and it requires some extensive knowledge. I have tried finding the answers myself online and in my book, so this is the last thing I know to do. These three questions are based on specifically cancer. I need detailed explanations PLEASE!!!!! Someone please help!!!! Thank You!!!!

Why was p63 and p73 function as tumor suppressor hard to confirm

        a.     knock out is lethal early on masking adult function

        b.     p53 can substitute for them when they are knocked out

        c.     p53s function in embryogenesis masks their function

        d.     they are not consistently expressed

        e.     none of the above

15. Germline mutations can influence cancer susceptibility in all of the following ways except

        a.     directly alter the growth of a cancer cell

        b.     alter mutation rate in somatic cells

        c.     modulate the metabolism of carcinogens

        d.     decrease the cells motility

        e.     all of the above are influences of germline mutations

16. The goal of the newer next generation of sequencing techniques in cancer research is to

        a.     sequence all genes in a tumor to determine mutational causes

        b.     identify all protein products with mutations

        c.     sequence whole genomes of tumors compared to the same person’s normal tissue genome

        d.     sequence mRNAs to determine expression levels

        e.     none of the above

Explanation / Answer

14. The answer is

b.     p53 can substitute for them when they are knocked out

Thus, p53 family proteins take on functions within a wide biological spectrum stretching from development (p63 and p73), DNA damage response via apoptosis and cell cycle arrest. p63 and p73 knockouts exhibit severe developmental abnormalities but no increased cancer susceptibility, whereas this picture is reversed for p53 knockouts.

15. The answer is

d.     decrease the cells motility

16. The answer is

c.     sequence whole genomes of tumors compared to the same person’s normal tissue genome

Identify more genetic determinants of cancer there is a greater need to adopt multi-gene assays that can quickly and reliably sequence complete genes from individual patient samples.

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.