Hemoglobin\'s Affinity for Oxygen. What is the effect of the following changes o

Question

Hemoglobin's Affinity for Oxygen. What is the effect of the following changes on the 02 affinity of hemoglobin? 3. a) A drop in the pH of blood plasma from 7.4 to 7.2. b) A decrease in the partial pressure of CO2 in the lungs from 6 kPa (holding one's breath) to 2 kPa (norml). c) An increase in the BPG level from 5 mM (normal altitudes) to 8 mM (high altitudes). d) An increase in CO from 1.0 parts per million (ppm) in a normal indoor atmosphere to 30 ppm in a home that has a malfunctioning or leaking furnace.

Explanation / Answer

Part a

A drop in pH from 7.4 to 7.2 will increase the affinity for oxygen affinity increases to myoglobin

oxygen affinity decrease to haemoglobin.

Therefore, less amount of O2 will be sucked into the lungs

Part b

Decrease the partial pressure of CO2 from 6 to 12 kPa

oxygen affinity decreases to myoglobin

oxygen affinity increases to haemoglobin

Part c

An increase in BPG levels from 5mM to 8mM

oxygen affinity increases to myoglobin

oxygen affinity decrease to haemoglobin.

Part d

increase in concentration of CO from 1 ppm to 30 ppm

oxygen affinity increases to myoglobin

oxygen affinity decrease to haemoglobin.

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