A biochem question, please answer in details! 2,3-Dideoxyinosine has been approv

Question

A biochem question, please answer in details!

2,3-Dideoxyinosine has been approved as an anti-HIV drug. Propose a mechanism by which it might block the growth of the HIV virus Dideoxyinosine (ddI) is taken up into the cell and converted to the corresponding dideoxynucleoside 5' triphosphate, ddITP. Incorporation of this nucleotide readily than the cellular replicative polymerases do, causing incorrect replication and accumulation of errors in the viral genome reducing its viability Dideoxyinosine (ddI) is taken up into the cell and converted to the corresponding dideoxynucleoside 5' triphosphate, ddITP. Incorporation of this nucleotide exonuclease, so it incorporates ddITP more readily than do the cellular replicative polymerases, causing replication of the viral genome to be selectively O in place of dGTP would create mistakes in replication because of frequent base substitutions. The HIV reverse transcriptase incorporates ddITP more in place of dGTP would block further chain elongation because of the absence of a 3' hydroxyl terminus. The HIV reverse transcriptase lacks a 3 inhibited Dideoxyinosine (ddI) is taken up into the cell and converted to the corresponding dideoxynucleoside 5' triphosphate, ddITP. Incorporation of this nucleotide ddITP more readily than the cellular replicative polymerases do, causing incorrect transcription and manufacturing incorrect proteins that reduces lifetime of in place of dGTP would create mistakes in translation and transcription because of frequent base substitutions. The HIV reverse transcriptase incorporates the host cell and induces an immune response

Explanation / Answer

1. Answer: Option b

Because a dideooxyinosine is also known as Didanosine. It is a nucleoside analogue that acts as a chain terminator by incorporation and inhibits viral reverse transcriptase by competing with natural dATP.

Part A:

Answer: Option b

Lac promoter more closely resembles the consensus -35 and -10 sequences than does either trp or lachas 12 out of 12 identities with the consensus sequence, where as each of lac and trp has 9.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.