In the following pedigrees, the disorders or traits presented follow simple patt

Question

In the following pedigrees, the disorders or traits presented follow simple patterns of Mendelian inheritance. For each pedigree, determine the most probable mode of inheritance of the trait, stating whether the trait is due to an autosomal or X-linked gene, and whether it is due to a dominant or recessive allele. Indicate and explain the evidence supporting your choice of pattern, and note evidence that does not support or conclusively eliminates the other patterns. Provide specific examples to defend your statements.

Then, providing a legend for your symbols, assign genotypes to the specified individuals. (BELOW)

Pedigree A

Provide genotypes for individuals I-4, II-2, III-12, and IV-2.

& From

Pedigree B

Provide genotypes for individuals I-2, II-4, III-2, and IV-8.

please oNLY ATTEMPT IF GENETICS IS YOUR SPECIALTY!!

Explanation / Answer

Pedigree A

Autosomal dominant inheritance

Reasons

The trait is equal in both male and female

Each affected individual has an affected parent

None of the generation is skipped

Both male and female are likely to be infected

Nearly 50% offspring of an affected individual are affected

Genotype

I-4 Aa heterozygous affected

II-2 aa homozygous normal

III- 12 Aa heterozygous affected

IV-2 aa homozygous normal

Pedigree B

X linked recessive inheritance

Reasons

The trait is never passed from father to son

Only males are likely to be affected

The trait is passed only through the mother

Genotypes

I-2 Ff heterozygous normal

II-4 Ff   heterozygous normal

III-2 Ff heterozygous normal

IV-8 Ff heterozygous normal

Individual is affected if both the alleles are recessive (ff)

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