In the following pedigree, the disorders or traits presented follow simple patte
ID: 93562 • Letter: I
Question
In the following pedigree, the disorders or traits presented follow simple patterns of Mendelian inheritance. For each pedigree, determine the most probable mode of inheritance of the trait, stating whether the trait is due to an autosomal or X-linked gene, and whether it is due to a dominant or recessive allele. Indicate and explain the evidence supporting your choice of pattern, and note evidence that does not support or conclusively eliminates the other patterns. Provide specific examples to defend your statements. Then, providing a legend for your symbols, assign genotypes to the specified individuals. (20 marks)
Pedigree A 1-0 OT 2 979 9-1069 0-10 I III 00!![ 10 1041 0 12T13 91 10 11 12 13 23 9 5 2Explanation / Answer
The disorder follows autosomal recessive form of inheritance. Because, the disease trait appears equally in males and females. It tends to skip generations. Two affected persons would have affected children (check II 6+II 7-III 9 and III 12)
Consider the genotypes AA (for uninfected), Aa (for carrier)
aa (for diseased)
(1) Then the genotypes for I1, I4, II4, II6, II7, III 4, III 7, III 9, III 12 would be aa.
(2) I2, I3, II2, II3 would have the genotype Aa.
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