In the following pedigree 5 individuals are suffering from retinoblastoma Consid

Question

In the following pedigree 5 individuals are suffering from retinoblastoma Considering the incomplete penetrance for this disease:

The probability that the newborn (IV-1) would suffer from RB is . . . . .

And The probability that the newborn (IV-1) would be homozygous for the RB alleles is (Mutation rate for this gene is 10-4) . . . . .

In the following pedigree 5 individuals are suffering from retinoblastoma Considering the incomplete penetrance for this disease: The probability that the newborn (IV-1) would suffer from RB is . . . . . And The probability that the newborn (IV-1) would be homozygous for the RB alleles is (Mutation rate for this gene is 10^-4) . . . . .

Explanation / Answer

probablity of getting RB: 0.5

probablity of being homozygous:0.12

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