A student loaded a compound mixture onto a column using 2 mL of dichloromethane
ID: 820067 • Letter: A
Question
A student loaded a compound mixture onto a column using 2 mL of dichloromethane as the loading solvent. The student then eluted the column using pet roleum ether. After collecting 8 fractions, the student analyzed them by TLC to find that all of the compounds came off in the first two fractions, with no separation. Where did the student go wrong? A student loaded a compound mixture onto a column using 2 mL of dichloromethane as the loading solvent. The student then eluted the column using pet roleum ether. After collecting 8 fractions, the student analyzed them by TLC to find that all of the compounds came off in the first two fractions, with no separation. Where did the student go wrong? A student loaded a compound mixture onto a column using 2 mL of dichloromethane as the loading solvent. The student then eluted the column using pet roleum ether. After collecting 8 fractions, the student analyzed them by TLC to find that all of the compounds came off in the first two fractions, with no separation. Where did the student go wrong?Explanation / Answer
He made mistake in running column. He should changed the polarity of the solvent, He should used low polar solvent like pentane, tolune mixture (~ 5 % tolune in hexane).
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