What is Reversal Potential? Why do currents have different directions (inwards v

Question

What is Reversal Potential? Why do currents have different directions (inwards vs. outwards) on either side of the reversal potential? The magnitude and direction of End Plate Current (EPC) is given by the following equation: EPC = g (V_m - E_rev). g rightarrow conductance V_m rightarrow Membrane potential E_rev rightarrow Reversal Potential In a voltage clamp experiment, V_m for your favorite postsynaptic neuron is held at the same value as the E_Na+ (Nernst Potential for Na+ ions) for the neuron which is +70 mV. The E_rev for your favorite postsynaptic neuron is +10 mV. Assume that g = 1. i. Describe the type (what ions will flow) of EPC, ii. Which direction will the EPC flow? iii. What is the magnitude of the EPC that will be generated upon a strong stimulation. iv. At what voltage will there be NO current in either direction? v. At what voltage will the EPC switch to the opposite direction How does summation work to integrate spatial and temporal signals? Suggest 3 benefits (for a neuron that is part of a neural circuit) of being able to sum (algebraically speaking) EPSPS and IPSPS. Explain why an Acetyl Choline receptor blocker causes paralysis while a GABA receptor blocker causes seizures

Explanation / Answer

Acetylcholine is a neurotransmitter which plays a key role in PNS. It activates the muscles. So whenever it is inhibited, the person can have paralysis and convulsions.

GABA is an inhibitory role as a neurotransmitter. Its function is to relax the neurons in the brain. This prevents these neurons from getting exciting or firing nerve impulses. Again, if its function is prevented, it leads to uncontrollable fires or action potential generated in neurons in the brain and lead to seizures.

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