EC50 value defines the potency of the drug.Compare the two results. State which
ID: 83243 • Letter: E
Question
EC50 value defines the potency of the drug.Compare the two results. State which agonist is the more potent of the two and explain briefly why. and state which agonist is the more efficacious of the two and explain briefly why.
In the first graph, EC50 value is 10000 and 25000 in the second graph.
Generic Dose-response curve Horizontal asymptotes of the curve are used to calculate the "maximum response". ie. maximum response S assay response at upper limit assay response at background limit upper limit half-maximum response halfway between the upper and background limits within the linear portion of the graph EC50 value- the agonist concentration giving the half maximum response The label for background limit KL this axis would correspond to [Agonist] the assay being run, in our case this would Plot this on a logarithmic scale. be induced CAMP The units for this axis would be units of the agonist concentration Amount (pMole) used in the assay...in our case this would be "nM for forskolin.Explanation / Answer
EC50 referes to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time. Its commonly used as a measure of drug's potency. The first drug with EC50 value 10,000 will be more potent than the drug with EC 50 value 25000.
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