The following question is for my self study reference. Please! help me solve all
ID: 884463 • Letter: T
Question
The following question is for my self study reference.
Please! help me solve all 4 sub parts. Thank you so much !
Below is the structure of an antiretroviral drug, Zalcitabine which is a modified nucleotide. NH2 Ho What nucleoside/nucleotide does this drug "mimic"? What micleoside mcleotide does this ii What structural feature of the nucleotide/nucleoside has been modified? iii) This drug will be taken up by the cell and rapidly phosphorylated to the nucleotide triphosphate. As a nucleotide triphosphate what cellular process might this modification interfere with and why? iv) What retroviral enzyme is it targeting and why does it have less effect on host cell enzymes?Explanation / Answer
a) the drug mimic pyramidine cystidine ( nucleoside)
b) It is made by replacing the hydroxyl group in position 3' with a hydrogen of deoxy cystidine.
c) Due to absence of hdyroxyl group in it , it act as terminating agent during chain elongation.
d) It is targeting reverse transcription and hence it is an inhibitor for reverse transcriptase.
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