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Chemotrypsin is a serine protease enzyme that continues to be widely studied to

ID: 901396 • Letter: C

Question


Chemotrypsin is a serine protease enzyme that continues to be widely studied to examine structure - activity relationships. the physiological substrates are proteins, but many non-physiological substrates are used to simplify the activity assay. One such substrate is ethyl N-acetyl-L-tyrosinate.

Inhibition studies were conducted with the two competitive inhibitors, benzeneboronic acid and benzylalcohol, and the ki values determined.

1) propose another competitive inhibitor to test and predict whether it would have a higher or lower ki value. refer to specific interactions that this proposed inhibitor may have with the active site


Explanation / Answer

sol: Diagram is not visible clearly

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