POGIL: oxygen Gas Transport & Blood Oxygen Content Model 1: Oxygen Binding to a

Question

POGIL: oxygen Gas Transport & Blood Oxygen Content Model 1: Oxygen Binding to a Single Hemoglobin Molecule in blood by two ways: dissolved in oxygen is transported plasma and bound to hemoglobin e98.5% of blood in mlb) is a large molecule consisting of four peptide chains. Each peptide contains a heme group with an iron in the center. An oxygen molecule has the ity to bind to each beme group under the appropriate conditions. The number of oxygen molecules bound determines its saturation, 1. When a hemoglobin molecule is completely saturated, how many oxygen molecules are attached 2. When a hemoglobin molecule is 75% saturated, how many oxygen molecules are artached? 3, Assuming you started with the molecule in Model 1. how many molecules of oxygen would need to be released in order for the hemoglobin to be 75% saturated? 4. The number of oxygen molecules bound to hemoglobin tends to fluctuate up and down. Where in the body is new oxygen most likely to be loaded (bind to hemoglobin) where in the body is axygen molecules unloaded (released from hemoglobin) 5. Is it possible for a single hemoglobin molecule to be 82% saturated? Why or why not? 6. There are 250 million hemoglobin molecules per red blood cell. How many molecules of oxyge can one red blood cell carry? 7. If after passing through a capillary bed, a 100 molecules of hemoglobin leave the capillary bed 75% saturated, how many molecules of oxygen were unloaded (released)? 8. Loading and unloading of oxygen is a reversible equation: HHb O2 HbO2 H+ a) Provide the specific name for the two hemoglobin molecules. b) Which direction (right or left) will the equation move in lung? c) Which direction (right or left) will the equation move in tissue? 9. Is it possible for a red blood cell to have total hemoglobin of 82% saturated? Explain. Additional Hemoglobin Binding Notes: Loading and unloading of oxygen is cooperative. After first molecule binds to iron, the hemoglobin changes shape. As a result Hb more readily takes up second o molecules and uptake remaining oxygen molecules is even more facilitated. Similarly, unloading one molecule enhances the unloading of the next oxygen.

Explanation / Answer

Answer:

1. Hemoglobin molecule has 4 polypeptide chains and 1 molecule of oxygen can bind to each. So, 4 molecules of oxygen is attached to hemoglobin when it is completely saturated.

2. 3 molecules of oxygen is attached to hemoglobin when it is 75% saturated.

Explanation:

At 100% saturation, 4 molecules of oxygen can bind.

So, for 75% saturation, 4/100 x 75 = 3 molecules of oxygen can bind.

3. As explained in answer 2, for 100% saturation, 4 molecules of oxygen should bind to hemoglobin while 3 molecules of oxygen should bind for 75% saturation. Thus, 1 molecule of oxygen need to be released in order for the hemoglobin to be 75% saturated.

4. a. New oxygen binds to hemoglobin in the lungs.

b. Oxygen is released from hemoglobin to various tissues and organs of the body as it travels through the capillary beds.

(Since there are multiple subparts, the first 4 subparts have been answered according to the rules of Chegg)

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