10. How many total MHC Class I (HLA-A, HLA-B, and HLA-C) genes do A. Three B. Si
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10. How many total MHC Class I (HLA-A, HLA-B, and HLA-C) genes do A. Three B. Six C. Twelve D. A lot, but less than 1000 E. ~1018 you personally have? 11. The expression of transmembrane and secreted forms of the antibodies occurs by? A. Genomic recombination B. RNA splicing C. by somatic hypermutation D. B and C only E. A and B only 12. Which immunoglobulin is found in tears? A. IgA B. IgM C. IgG D. IgE E. IgD 13. What kind of MHC does a cytotoxic CD8+ T cell recognize? A. MHC Class I B. MHC Class II C. MHC Class III D. All of the above E. A and B only 14. Which of the following things is considered not a part of the innate immune response? A. Natural Killer cells B. neutrophils C. CD4+ T lymphocytes D. complement E. All of the things above are part of the innate immune responseExplanation / Answer
10. Option A is correct. In humans, the MHC complex consists of more than 200 genes located close together on chromosome 6. Genes in this complex are categorized into three basic groups: class I, class II, and class III. Humans have three main MHC class I genes, known as HLA-A, HLA-B, and HLA-C.
11. Option E is correct. L chain gene segment recombination occurs for the expression of transmembrane and secreted form of antibodies. RNA splicing removes excess base pairs to allow translation of a complete kappa chain.
12. Option A is correct. IgA is the main immunoglobulin found in mucous secretions, including tears,saliva, sweat, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood.
13. Option A is correct. CD8+ T cells recognise peptides presented by MHC Class I molecules.
14. Option C is correct. CD4+ and T lymphocytes help innate immune cells.
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