Gene expression: Understand the question on DNA coding and mutational consequenc

Question

Gene expression: Understand the question on DNA coding and mutational consequence as shown in the lecture slide. What are the subcellular locations for DNA replication, transcription and translation? How are they coordinated? What model organisms are frequently used for biological or medical research? What are their advantages and disadvantages? Arabidopsis floral ABC model: what are the phenotypes of a b, b, c, and a c double mutants? Use of the transgenic approach to create novel flowers or plants? What are homeotic mutations? What are the implications from these mutations in the genetic control of animal development? The most common genetic cause leading to Angelman syndrome is deletion or inactivation of an ~ 4Mb (mega base) maternal deletion in chromosomal region 15ql1 - 13 while the paternal copy is imprinted. How would you design a strategy to show which gene(s) in this region are responsible for the disease. What approach can you use to develop a system for drug testing? What is the relationship between epigenetic regulation and gene expression? Why genome editing is so powerful in modem biomedical research? Any disadvantage or uncertainty? Regulatory aspects for the New Breeding Technology (NBT)?

Explanation / Answer

1) Model organisms are used to obtain information about other species which are difficult to obtain directly. The commonly used model organisms are Drosophila melanogaster. Their advantages and disadvantages are listed below.

Advantages:

Disadvantages:

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