What is a 0.05% w/v solution in micrograms/ml? The prescription is for a sugar-f

Question

What is a 0.05% w/v solution in micrograms/ml? The prescription is for a sugar-free oral solution of furosemide (Frusol ). What is the concentration of the stock in mg/ml if a 5 ml dose contains 40 mg of the drug? The daily therapeutic dose of ceftriaxone (Rocephin ) for infants and children of up to 12 years is 20-50 mg/kg body weight. What is the maximum daily dose for a 10-year-old child weighing 38 kg? The weight of a child up to age 10 years can be estimated from the equation: weight in kg = 2 times (age + 4). Estimate the weight of a seven-year-old child?

Explanation / Answer

Question Part 1:

0.05% w/v means 5 grams dissolved in 100 ml of solution. Converting 5 gms into mg, we get 5000 mg. Hence, concentration in mg/ml = 5000/100 = 50mg/ml.

Question Part 2:

40 mg of drug is present on 5 ml dose. Hence, concentration in mg/ml is 40mg/5ml = 8mg/ml.

Question Part 3:

The 10 year-old boy weighs 38 kg. Daily dose of kids upto 12 years is 20 -50 mg/kg. Hence, minimum dose for 38kg boy = 20 X 38 = 760mg. And, maximum dose for 38 kg boy = 50 X 38 = 1900 mg or 1.9 grams.

Question Part 4:

Weight = 2 X (age +4)

Age = 7 (given)

Hence, weight = 2 X (7 + 4) = 22 kg.

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