What is the sequence of the products of the oligopeptide Ala-Gly-Ser-Gly-Arg-Ser

Question

What is the sequence of the products of the oligopeptide Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp?

Urokinase-type Plasminogen Activator (nPa) is a serine endopeptidase. The active site of this peptidase binds the peptide-inotif Ser-Gly-Arg-Ser-Ala and cleaves the protein/peptide between arginine and serine. What is the sequence of the products of the oligopeptide Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp after cleavage by uPa? Ala-Gly and Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp Ala-Gly-Ser-Gly-Arg and Ser-Ala-Lys-Gly-Ala-Ser-Asp Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser and Asp Ala-Gly-Ser-Gly-Arg-Ser and Ala-Lys-Gly-Ala-Ser-Asp

Explanation / Answer

Ala-Gly-Ser-Gly-Arg-NH-C=O-Ser-Ala-Lys-Gly-Ala-Ser-Asp

Peptide linkage is denotedby (-CONH-)

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