In this paper the authors are trying to understand why the rate of amdinocillin

Question

In this paper the authors are trying to understand why the rate of amdinocillin resistance is high in laboratory isolates, despite resistance in clinical isolates rarely occurring. This paper illustrates why lab derived mutations are not necessarily the same as those that occur in clinical isolates.

1. Based on Figure 1 what is the dominant genotype of the amdinocillin resistant clinical isolates? Which strain in supports your conclusion?

BIOL 371 Microbiology Figure 1. Mutated genes present in twelve amdinocillin resistant clinical isolates. The far left column lists the mutated genes and the top row describes the strain name for each clinical isolate. Gray shaded boxes indicate the individual genes mutated for each clinical isolate glix alas FIG 1 Putative Amd resistance-encoding genes i clinical strains. Genes marked by gray shading have a mutation that is not present in any of the reference genomes. Specific mutations are listed in Table 4

Explanation / Answer

From Figure 1, it could be seen that cysB gene was mutated in all of the clinical isolates suggesting that cysB could be the dominant genotype  in generating Amd resistance in clinical E. coli isolates. All the strains supports this conclusion because all the strains exhibited the mutation of cysB gene.

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