A patient suffers from hemolytic anemia. You suspect an enzyme deficiency in the

Question

A patient suffers from hemolytic anemia. You suspect an enzyme deficiency in the pentose phosphate pathway.  Which of the following enzymes would be the most likely candidate for this deficiency?

Answers:

glucose-6-phosphate dehydrogenase

Malic enzyme

Glutathione reductase

6-phosphogluconate dehydrogenase

A patient suffers from hemolytic anemia. You suspect an enzyme deficiency in the pentose phosphate pathway.  Which of the following enzymes would be the most likely candidate for this deficiency?

Answers:

glucose-6-phosphate dehydrogenase

Malic enzyme

Glutathione reductase

6-phosphogluconate dehydrogenase

Explanation / Answer

The first option is correct. This is because glucose-6-phosphate dehydrogenase is an enzyme involved in pentose phosphate pathway in which NADPH is produced. NADPH maintains the reduced levels of glutathione which prevents the fragility of RBC's. Deficiency of NADPH due to defective glucose-6-phosphate dehydrogenase lowers the levels of reduced glutathione thereby making RBCs fragile and causing hemolytic anaemia.

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