Question
please I need help with 2.4 and 2.5 only .Thanks
Question 2 Coat color variation in mammals has long served as one of most fruitful examples of genetics, with over 120 loci and 800 alleles affecting coat color described in mice alone, For this question, we will consider the adaptive transition from d to light coat coloration that accompanied the movement of mice from the fores he beach species was more among two species of mouse. The ancestral species was darkly colored while the derived mouse living on lightly colored consistent with the sclective pressures that come a dark lightly colored when you are representative sand. The phenotypes of the rwo parental species, along with a individual and represent from the F2 below. generation are shown 2.1 (10) Assume that you only had the data shown above for the parental lines ancestral and derived species and the F1. What inferences would you make about the mode of inheritance for the overall (whole body) coat color? Support your inferences clearly [do not just write the mode of inheritance, explain why you arrived at that answer 2.2 (10) With the added data from the F2, what inferences might you make about the mode of inheritance for the overall (whole body) coat color? Support your inferences clearly ldo not just write the mode of inheritance, explain why you arrived at that answer Researchers performed genetic mapping experiments to locate genes involved in the determination of pigmentation and found two loci MCIR (chromosome 1), and AGOUTI (chromosome 7) that both affect pigmentation. Each of these loci have two alleles, one associated with light coloration (the Lallele) and one associated with the dark coloration (the D allele). When the researchers analyzed the effect of the alleles at these two loci on cheek coloration, the following results were obtained. The y axis of the graph is a measure of color where low numbers represent dark coloration and large numbers represent lighter coloration
Explanation / Answer
2.4 The awb allele is dominant and is a cis-acting mutation which lead to increased expression of Agouti gene. As shown in the picture, the heterozyoutes a+/awb shows higher expression of Agouti than the wild-type which confirms tha the mutation acts in cis. The mutated allele is dominant and is expressed in high quantities. The phenotypic effect of the mutation is wideband
The mutations probably existed either in the regulatory region or in the exons. The mutation changed the phenotype of the gene.
