8. The reaction below might be a suitable couplod reaction to provide the energy

Question

8. The reaction below might be a suitable couplod reaction to provide the energy for which of the following reactions (A-E)? Explain your choice. (3pts) phosphocreatine + H,o creatine + Pi G-10.3 kcal/mol + 145 kcalmol 0' …11.8 kcalmol A. Pyruvate + Pi phosphoenolpyruvate + H MG" &Gr; +7.3 kcalmol C. D. 3-phosphoglycerate + Pi 1,3-bisphosphoglycerate* H,O Malate + NAD. oxaloacetate «NADH + H. E. Glucose-l-pbosphate + H:O glucose+ Pi 9. A) Using the information from problem 9, write the equation for the hydrolysis of ATP (p). B) Determine AG for the hydrolysis of ATP (see info. in problem 9)(1p C) The actual concentrations of ATP, ADP, and Pi differ with cell type as shown below, Consequently, the release of free energy with the hydrolysis of ATP will vary with cell type. Calculate the GG for the hydrolysis of ATP in muscle, liver, and brain cells (assume 25'C andMue Liver 35 5.0 8.0 0.9 0.7 26 energy of ATP hydrolysis greatest? (4 pts)

Explanation / Answer

Answer:B

Phosphocreatine is used to coupled in the formation of ATP from ADP in muscles every time we exercise vigorously. Phosphocreatine has higher free energy change of 10.3Kcal/mol compared to ATP which has only 7.3kcal/mol. Hence this reaction is coupled in muscle to generate ATP from ADP during exercise.

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