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NADH from the citric acid cycle binds at Complex I of the electron transport sys

ID: 197287 • Letter: N

Question

NADH from the citric acid cycle binds at Complex I of the electron transport system NAD*. The NADH in glycolysis doesnt tollow the same path, although it does possess energy due to being reduced by glyceraldehyde-3-phosphate dehydrogenase. What is the issue with NADH from glycolysis not being oxidized at where it is oxidized back to Complex I of the electron transport system? ONADH cannot diffuse across mitochondrial membranes O cytosolic NADH doesnt possess as much reductive potential as mitochondial NADH cytosolic NADH is different from mitochondriai NADH cytosolic NADH undergoes oxidative phosphorylation within the nucieus cytosolic NADH oxidizes to FAD instead of NAD-

Explanation / Answer

Answer: NADH cannot diffuse across mitochondrial mmembranes

Explanation:

NADH cannot simply pass into mitochondria for oxidation by the respiratory chain, because the inner mitochondrial membrane is impermeable to NADH and NAD+.