The figure below is from Supplemental figure 5B from the paper below Wang, Lili

Question

The figure below is from Supplemental figure 5B from the paper below

Wang, Lili et al. 2011. SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia. New England Journal of Medicine. 365:2497-2506. + supplementary material.

Please answer the following questions

Supplemental figure 5B presents Kaplan-Meier curves for what? In other words, what is the X axis? Why is this measure meaningful?

Figure Legend

1.0 Discovery set (n-91) Extension set (n=101) p 0.001 p 0.001 No del (11q). No SF3B1-K700E 0.5 No del (11q), No SF3B1 mut SF3B1 mut del (11q) 80 Months from diagnosis 80 160 240 O 160 240

Explanation / Answer

In the figure 5B presenting Kaplan-Meier curves, the curves represent the probability of patients (% of affected) responding to first therapy or treatment on Y - axis and duration of treatment is represented on x - axis. The category of patients included are 91 patients in discovery set and 101 patients in extension set. In both the discovery and extension sets, the patients have mutations del (11q) and SF3B1 which are present or absent. Form the graph, it is evident tat patients having one or both mutations responded to treatment with in short duration than patients containing only one or no mutation.

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