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What limits the use of differences in restriction enzyme sites as a way of detec

ID: 252518 • Letter: W

Question

What limits the use of differences in restriction enzyme sites as a way of detecting point mutations in human genes?

a_ DNA regions that are inaccessible to restriction enzymes are commonly present near the chromosome centromere.

b) The close similarity in terms of base sequences of many non-coding regions of human genome.

c) Relatively low number of available restriction sites in the regions of genome with mutations.

d) The possibility of mutations in the sequences recognized by restriction enzymes.

What is a “profile probability”?

A profile probability provides a mathematical probability that DNA profile of a sample obtained in a single laboratory test completely corresponds to its real DNA profile. A profile probability provides a mathematical probability that a random DNA sample shares the same DNA profile as another sample from this population. A profile probability provides a mathematical probability that DNA profile acquired from a sample is not influenced by any contamination. A profile probability provides a mathematical probability that an evidence sample matches a suspect's sample, if they come from the same person.

Explanation / Answer

B)

3.      The DNA profile then helps us in solving the case if the two samples match.

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