Calculate renal clearance rates and relate them to kidney function C_Cr = U_Cr t

Question

Calculate renal clearance rates and relate them to kidney function C_Cr = U_Cr times V/P_Cr A person has a plasma creatinine concentration 0.001 mg/ml and in 1 hour produces 60mk of urine with a creatinine concentration of 1.25 mg/mL. C_Cr = 1.25 mg/mL times 60 mk/60 min/0.01 mg/mL = 1.25 mg/mL times 1mL/min/0.01 mg/mL = 1.25 mg/min/0.01 mg/mL = 125 mL/min Ms. B came into the hospital after losing a lot of blood in a motorcycle accident. After her condition is she was given a creatinine clearance test to estimate her glomerular filtration rate. Creatinine is a substance that much filtered into the urine but neither reabsorbed nor so you can tea how much blood was filtered by how creatinine goes out in the urine. Plasma creatinine levels = 0.1 mg creatinine/mL blood Urine creatinine levels 16 mg creatinine/mL urine Urine production = 0.5 mL urine/min What was her creatinine clearance rate (mL blood/min)? You should be able to solve this in one step by lining conversion

Explanation / Answer

Answer:

Creatinine clearance (Ccr) = [urine creatine levels (Ucr) * urine production (V)] / [plasma creatinine level (Pcr)]

Given Ucr ---> 16 mg mg creatinine/mL

urine production (V) --> 0.5 mL urine/min

plasma creatinine level (Pcr) --> 0.1 mg creatinine /mL of urine

Creatinine clearance (Ccr) = [urine creatine levels (Ucr) * urine production (V)] / [plasma creatinine level (Pcr)]

   = [16 * 0.5] / [0.1] --> 80 mL/min

Ques-2:

Her kidneys are not functioning properly because normal creatinine clearance in a health female is 88–128 mL/min but in her it was 80 mL/min

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