Resting membrane potential of nerves and skeletal muscles fibers. Main and compl

Question

Resting membrane potential of nerves and skeletal muscles fibers. Main and complimentary factors, which influence on a value of the resting membrane potential. Action potential: the structure, physical and physiological characteristics. Structure and basic properties of ionic protein channels, which take part in development of active potential. Voltage-gated sodium and potassium channels. Ionic mechanisms of development of basic phases of action potential. Initiation of the action potential: a positive-feedback mechanism, threshold for initiation of the AP.

Explanation / Answer

6.Resting membrane potential is important in nerves and skeletal muscles fibers or cells because changes in their membrane potential are used to code and transmit information.

7.Action potential:

Structure: It is the brirf electrical impulse which is responsible for propagation of information down the axon of a neuron.

Physical characteristics: Action potential demonstrates how changes in membrane can constitute a signal.A mechanically gated channel opens because of physical distortion of cell membrane.

Physiological characteristics: It is basis of communication in action potential how changes can interact with the charge of ions because of varied properties of aminoacids.

8.Structure:

Ionic protein channels are molecules which are integral membrane proteins that span the plasma membrane repeatedly.

Properties:

The proteins that function as voltage gated channels have properties like opening in response to changes in membrane potential, subsequent channel closing and inactivation and exquisite specificity for those ions that will permeate and those that will not.

9.It includes phases like voltage dependent conductances, sodium inactivation, voltage dependent potassium conductance, sequence of conductance changes underlying the nerve action potential, pharmacology of volatge dependent membrane channels, pumps and leaks , types of membrane channels, channelopathies, absolute and relative refractory periods and action potential laboratory.

10.Positive feed back mechanism is sustained by intrinsic properties of neuron namely voltage dependence of ionic conductance in which action potential is self supporting or regenerative.

Threshold potential is the critical level to which a membrane potential must be depolarised to initiate an action potential.

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