Cell Biology Please Need Help With Problem ( Part 4) Please and Thank you in adv

Question

Cell Biology

Please Need Help With Problem ( Part 4)

Please and Thank you in advance!

4. (2 points) You are given cDNA sequences encoding four proteins. From sequence analysis, they have the characteristics shown below. NOTE: The N-terminus is on the left, the C-terminus is on the right, |||||| is a predicted hydrophobic region of at least 20 amino acids, is a predicted hydrophilic region Where would you predict each of these products to be found (in cytosol, inside organelle, or outside cell, be specific)? Explain your logic.

Explanation / Answer

hydrophilic protein can be in the cytoplasm

Proteins with 5' end hydrophobic can be transmembrane with hydrophobic exposed or inside

KEEL motif signs for ER retention, so it will be in ER

KDEL at N orC terminus will be targated to ER . so it will be in ER

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