B. Below is a segment of coding sequence from the overlapping Ink4A-Arf locus (t

Question

B. Below is a segment of coding sequence from the overlapping Ink4A-Arf locus (top line) and protein sequence from Ink4A (line 2, zero frame) and Arf (line 3, +2 frame).

caggtcatgatgatgggcagcgcccgagtggcggagctgctgctgctccacggcgcggag

Q V M M M G S A R V A E L L L L H G A E

G H D D G Q R P S G G A A A A P R R G

-What bases could be used to maintain this Leucine codon in Ink4A but mutate the Proline codon in Arf?

- What amino acid codons could be introduced into Arf Proline codon without changing the Ink4A Leucine codon?

Explanation / Answer

CTC can be used to maintain Leucine codon in Ink4A and CCA can be used to mutate proline codon in Arf (CTCCAC).

Histidine coding triplet codon CAC can be introduced into Arf proline codon.

Hope I am correct...!!!

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