Question 1 is based on the following data collected from a normal resting person

Question

Question 1 is based on the following data collected from a normal resting person.

GFR = 135 ml/min

Urine flow rate = 1.20 ml/min

[Na+ ]plasma = 145 mEq/L

[Urea]plasma = 4.0 mmol/L

[Glucose]plasma = 4.50 mmol/L

[Creatinine]plasma = 0.12 mmol/L

[Na+ ]urine = 145 mEq/L

[Inulin]urine = 16.90 mg/ml

[Urea]urine = 240.0 mmol/L

[Creatinine]urine = 13.7 mmol/L

5. The rate at which plasma is being cleared of creatinine is similar to GFR. What statement(s) below is (are) consistent with this finding?

A. Creatinine is freely filtered at the glomerulus and there is very little secretion or reabsorption of creatinine along the entire length of the nephron

B. Creatinine clearance roughly equals inulin clearance

C. Creatinine clearance is a good estimate of GFR

D. The rates at which inulin and creatinine enter Bowman

Explanation / Answer

A. Since creatinine level in plasma is 0.12 mmol/L, Creatinine is freely filtered at the glomerulus and there is very little secretion or reabsorption of creatinine along the entire length of the nephron. True.

B. Creatinine clearance roughly equals inulin clearance. False. This is because creatinine is waste product produced by amino acid digestion whereas, inulin is a complex carbohydrate.

C. Creatinine clearance is a good estimate of GFR. True. This is because the the proteins are not passed through the filtration membrane. The waste product, creatinine is able to pass through the membrane and hence, The glomerular filtration rate can be estimated by efficience of creatinine filtered through membrane.

D. The rates at which inulin and creatinine enter Bowman

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