Given that about 400 billion mature hematopoetic cells are produced daily, the a

Question

Given that about 400 billion mature hematopoetic cells are produced daily, the assumed hayflick limit is 44-50, about 1:5000 progenitors do not go through apoptosis, about 50 to 1000 mature cells are made per progenitor (6-10 doublings), the entire differentiation pathway may be 17-20 doublings, and a maximum of about 10-30 million cells can be made from a highly purified single hematopoetic stem cell/progenitor cells in vitro

Do you think that that human hematopoetic stem cells truly self renew in vivo given the data? Present order of magniture calculations in your answer.

Explanation / Answer

Human hematopoetic stem cells really self renew by this given data.

The reason behind is that since one progenitor cells can be converted in to 10-30 million cells and nearly 1000 cells are made per progenitor, so if the given data of daily production of mature hematopoetic cell are 400 billion is true. then it can be possible in vivo also.

Let's explain it by order of magnitude calculation.

400 billion cells are 1000 times greater than the 10-30 million cell made by single progenitor and the up to 1000 mature cells are made by the single progenitor.

So, 30 million X 1000 = 400 billion approximately.

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