A mixture of 2-chloro-6-fluorobenzaldehyde 11(5 kg, XX mol), tert-butylpiperazin

Question

A mixture of 2-chloro-6-fluorobenzaldehyde 11(5 kg, XX mol), tert-butylpiperazine-1 - carboxylate (1-Boc piperazine) 9 (6.46 kg, XX mol), DIPEA (XX L, 47.23 mol), N-methyl-2-pyrrolidinone (25 L) was heated at 95 degree C overnight under a nitrogen atmosphere. The reaction mixture was cooled to room temperature a poured into a prepared mixture of water (33 L) and acetone (17 L). The resulting suspension was stirred for 15 min and filtered, and the wet cake was washed with water and dried to give a yellow solid, which was slurried in heated n-heptane (30 L) to give compound 12 (9.62 kg XX% yield) as a white solid containing 4% compound 15. HPLC for compound 12 (tR = 14.4 min, identical to authentic sample) 94% purity, compound 15 (tR = 7.6 min); HPLC method A Using the reaction scheme below, answer the following questions. What is the molecular weight of 2-chloro-6-fluorobenzaldehyde 11?

Explanation / Answer

2-Chloro-6fluoro benzaldehyde has molecular formula C7H4OFCl

Its molar mass = (12x7) + 4 + 16+ 19+35.3

= 158.5

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