QUESTION # 2: Antibioticresistance is a widespread public health issue. Explain

Question

QUESTION # 2: Antibioticresistance is a widespread public health issue. Explain whyresistance develops so quickly, spreads so rapidly and widely, andis so hard to eradicate. Describe how the R plasmid is involved inthe spread of multiple antibiotic resistance, and how the F factorplays a role. Next, describe three specific mechanisms ofantibiotic resistance. If you were a research scientist at apharmaceutical company, which of the three mechanisms you justdescribed would be the one you would select for development of newdrugs to combat resistance, and why? QUESTION # 2: Antibioticresistance is a widespread public health issue. Explain whyresistance develops so quickly, spreads so rapidly and widely, andis so hard to eradicate. Describe how the R plasmid is involved inthe spread of multiple antibiotic resistance, and how the F factorplays a role. Next, describe three specific mechanisms ofantibiotic resistance. If you were a research scientist at apharmaceutical company, which of the three mechanisms you justdescribed would be the one you would select for development of newdrugs to combat resistance, and why?

Explanation / Answer

the malarial parasite is having different stages in asexual andsexual cycle of life history.

so it is difficult to target parasite because the parasitechanges surface cell antigens also during each stage.

Sporozoites enter the blood stream from one person to anothertransferred ,When an infected mosquito sucks a blood mealfrom a person.The Sporozoite migrates to the liver , where theymultiply , transforming liver hepatocytes into gaint multinucleateschizonts, which release thousands of merozoites into the bloodstream.The Merozoites infect red blood cells, which eventuallyrupture , releasing more merozoites. Eventually some of themerozoites differentiate into male and female gametocytes which areinjested by a mosquito and differentiate into gametes. The gametesfuse to form azygote that differentiates tothe sporozoitestagewithin th e salivary gland of the mosquito

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