A researcher alters the hormone-binding sequence of an estrogen receptor to that

Question

A researcher alters the hormone-binding sequence of an estrogen receptor to that of a gluco-corticoid receptor. What may be the expected response of this receptor?

a. The estrogen receptor's activity will remain unaltered. The receptor will continue to strictly bind to estrogens

b. The estrogen receptor will become entirely deactivated and will neither bind to estrogens nor gluco=corticoids

c. The estrogen receptor may bind to gluco-corticoids if they are introduced into the cell

d. The estrogen receptor will be capable of binding to both gluco-corticoids and estrogens

e. None of the above

Explanation / Answer

Since the hormone binding domain sequence is altered to glucocorticoid receptor, then the estrogen receptor may bind to gluco-corticoids if they are introduced into the cell.

Hence, the correct option is c. The estrogen receptor may bind to gluco-corticoids if they are introduced into the cell

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