The reaction that converts oxaloacetic acid (OAA) to phosphoenol pyruvate (PEP)
ID: 78431 • Letter: T
Question
The reaction that converts oxaloacetic acid (OAA) to phosphoenol pyruvate (PEP) is an essential reaction in gluconeogenesis. The list below contains various compounds that are involved directly or indirectly in this OAA to PEP step. For ANY EIGHT items in this list, (a), name one compound or structure to which it binds when it functions in this process and (b). describe the function relating to the OAA to PEP step it carries out. Note that at least one of the compounds listed below does NOT participate in this process, and for each of them you should write NONE in the "Function" column. An example is show for glucagon below.Explanation / Answer
ANSWER:
COMPOUNDS:
1) CORTISOL
BINDS TO Glucocorticoid Receptor
FUNCTION passes through the lipid membrane of liver cells
2) CREB
BINDS TO CREB then binds upstream of the PEPCK-C gene at CRE and induces PEPCK-C transcription
FUNCTION PEPCK-C by increasing the levels of cAMP in the liver which consequently leads to the phosphorylation of S133 on a beta sheet in the CREB protein.
3)GRE
BINDS TO PEPCK-C
FUNCTION This receptor dimerizes and the cortisol/GR complex passes into the nucleus where it then binds to the Glucocorticoid Response Element.
4) cAMP
BINDS TO NONE
FUNCTION Glucagon indirectly elevates the expression of PEPCK-C by increasing the levels of cAMP.
5) Glucocoticoid Receptor
BINDS TO Glucocoticoid Receptor
FUNCTION Is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure
6) PEP-CK
BINDS TO NONE
FUNCTION It converts oxaloacetate intophosphoenolpyruvate and carbon dioxide. It is found in two forms, cytosolic and mitochondrial.
7) RIBOSOMES
BINDS TO None
FUNCTION
8) Lac Repressor
BIMDS TO None
FUNCTION
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