A translocation event from chromosomes 9 and 22 is reportedly responsible for ch

Question

A translocation event from chromosomes 9 and 22 is reportedly responsible for chronic myelogenous leukemia (CML). Your textbook states this event is irrefutable evidence that this type of cancer originates from a mutation event in a single cell. Briefly describe the evidence stated for this conclusion and state whether or not you believe this assertion. Be sure to explain the rationale behind your reasoning (i.e. why do you, or don’t you, believe this assertion based on some line of evidence or logic).

Explanation / Answer

answers:

Mutation events result in transformation of that single cell into cancer cells with its subsequent uncontrolled proliferation to generate a large number of daughter cells making up final neoplasm

Marker chromosome can be demonstrated in all of individual cells of the tumor, again common clonal origin from single eg: chronic myelogenous leukemia

clonality of most tumor suggest that genetic mutations are capable conferring a malignant phenotype

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