As your text points out, diseases tied to mutations in genes encoding proteins o

Question

As your text points out, diseases tied to mutations in genes encoding proteins of oxidative phosphorylation are being identified. Suppose a person had a mutation in a gene encoding one of the proteins of an electron transport complex. Of course, if the resulting defect were severe, the condition would be lethal. But let's suppose the condition is a relatively minor defect in electron transport. What would the long term consequences of that defect be?

A. A gradual accumulation of reactive oxygen species, any one of which could cause serious problems over the long term.

B. A total lack of ATP synthesis in oxidative phosphorylation and therefore a total reliance on glycolysis for ATP synthesis.

C. A total failure to create a proton gradient across the inner mitochondrial membrane.

D. A creation of a proton gradient by ATP synthase rather than in electron transport.

Explanation / Answer

A gradual accumulation of reactive oxygen species, any one of which could cause serious problems over the long term

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