Identify and briefly describe three of the processes by which deamination of DNA

Question

Identify and briefly describe three of the processes by which deamination of DNA-cytosine residues by AID could lead to mutagenesis. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. The most likely pathway would involve deamination of to, with the U templating on the next round of synthesis. Another possibility is for to create an abasic site after removing created by deamination, with then being inserted opposite that site during the, before the can be completed. A third possibility would be repair of the G - U mismatch by or, giving an pair that would replicate to give .

Explanation / Answer

Answer:

The most likely pathway would involve deamination of G-C to G-U, while the U templating A on the next round of synthesis. Another possibility is for UNG to create an abasic site after removing U created by deamination, with any base then being inserted opposite that site during the next round of replication, before the repair process can be completed. A third possibility would be repair of the G-U mismatch by mismatch repair or NER, giving an A-U pair that would replicate to give A-T.

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