Your research in hematology has led you to the discovery of a new type of inheri

Question

Your research in hematology has led you to the discovery of a new type of inherited anemia, which exists in two forms--mild and severe. The information you have gathered on the familial patterns for the disease is summarized below. From these data determine a mechanism for the inheritance of these traits that is consistent with all of the information. a. normal female times normal male = all normal children b. normal female times anemic male = 1/2 mild females = 1/2 normal males c. mild female times normal male = 1/4 normal males = 1/4 anemic males = 1/4 normal females = 1/4 mild females d. mild female times anemic male = 1/4 normal males = 1/4 anemic males = 1/4 mild females = 1/4 anemic females e. anemic female times normal male = 1/2 mild females = 1/2 anemic males f. anemic female times anemic male = all anemic children

Explanation / Answer

28. ANS: Normal (A) is incompletely dominant to anemic (a);

allele is sex-linked

AA = normal

Aa = mild anemia

aa = severe anemia

Genotype of crosses are:

a. AA x Ay

b. AA x aY

c. Aa x AY

d. Aa x Ay

e. aa x AY

f. aa x aY

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