Cellular & Molecular Biology question. Please give the corrects answers to quest

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Cellular & Molecular Biology question. Please give the corrects answers to questions b,c, and d. Thank you.

A representation of the drug bound to the E. coli ribosome is shown below. Three amino acids of the ribosome that are important for binding are shown. If this drug can bind to different bacterial ribosomes, it may be useful as an antibiotic. The ability of this drug to bind to the ribosomes of two different species is examined. The drug binds to the ribosome of species 1, but does not bind to the ribosome of species 2. For your information Amino acid Lys 101 Val Asn Glu Lys Ser Leu Side chain CHCH3CH2CHa CHCH CHa CH2CONH2 CH2CH2COO (CH2)4NH3+ CH2OH CH2CHCH3CHa (CH2)3NHC(NH2)2+ -1 , CH CH vLeu 312 (iv) l 'CH, (iii)) Ribosome b) The table shows the differences between the ribosomes. Given this information, complete the table indicating which would be from species 1 (drug binds) and which would be from species 2 (drug does not bind) Amino acid found at 231 Asn Ser Glu Ribosome from 101 312 Leu Val lle E. coli Glu Species Species c) What specific amino acid or amino acids prevents the ribosome from species 2 from binding Drug 1? d) In terms of the specific non-covalent interactions, explain why the ribosome from species 2 will NOT bind Drug 1, but the ribosomes from E. coli and species 1 will

Explanation / Answer

b) Lysine (101) is a positively charged amino acid which helps the ribosome of E.Coli to make interaction with the drug. Arginine (101) is also a positively charged amino acid which is from ribosome of species 1 which helps to bind with the drug easily. Glutamic acid (101) is a negatively charged amino acid which is from ribosome of species 2 which denies interaction with the drug.

c) glutamic acid prevents the binding of ribosome to the drug as it is negatively charged amino acid

d) Electrostatic interaction is one kind of non-covalent interaction which occurs between positively and negatively charged groups. So, E.coli and species 1 can make electrostatic interaction with drug but species 2 cannot as it has negatively charged amino acid

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