A 44-year-old white man consulted his primary provider because of pain in his sh

Question

A 44-year-old white man consulted his primary provider because of pain in his shoulder and fingers. The physical examination revealed no major abnormalities but his liver was slightly enlarged and tender. A CBC and blood studies were ordered, with the following results:

Parameter

Result

Reference Range

Hemoglobin

14 g/dL

14-18 g/dL

Hematocrit

42%

42-52%

Serum iron

37 µg/dL

50-160 µg/dL

Serum ferritin

2,430 ng/mL

15-400 ng/mL

% Saturation

95%

20-55%

A liver biopsy was performed. Tissue sections revealed fatty metamorphosis and an increase in fibrous tissue in portal areas consistent with early cirrhosis. Large amounts of parenchymal iron were noted with Prussian blue staining.

   Does this man have anemia? Why or why not? Based on the laboratory results and the patient history, what is the most likely diagnosis? What morphology would you expect to see in the peripheral blood?    What is the most common cause of this disorder?

Parameter

Result

Reference Range

Hemoglobin

14 g/dL

14-18 g/dL

Hematocrit

42%

42-52%

Serum iron

37 µg/dL

50-160 µg/dL

Serum ferritin

2,430 ng/mL

15-400 ng/mL

% Saturation

95%

20-55%

Explanation / Answer

In a Ferritin test, measures the amount of ferritin in your blood. Ferritin is a blood cell protein that contains iron. If the test reveals that your blood ferritin level is lower than normal, it indicates your body's iron stores are low and you have iron deficiency.

The serum transferrin receptor test can be used to help differntiate between iron deficiency anemia and anemia of chronic disease.

It clears that the man have iron deficiency anemia.

to diagnoseiron deficiency anemia, doctor may run test to look for:

1. Red blood cell size and color

2.Hematocrit

3.Hemoglobin

4.Ferritin

5.Endoscopy

6.Colonoscopy

In an individual who is anemic from iron deficiency, these test usually shows the following results:-

Low Hg and Hct

Low MCV

Low ferritn

Low serum iron

High transferrin or TIBC

Low iron saturation

CAUSE:

Iron deficiency anemia occurs when your body doesn't have enough iron to produce hemoglobin. hemoglobin is the part of red blood cells that gives blood its red color.If you are not takin enough iron, or if you are losing iron, your body can not produce enough hemoglobin and iron deficiency anemia eventually occurs.Causes of iron deficiency anemia includes:

BLOOD LOSS

LOSS OF IRON IN YOUR DIET

AN ABILITY TO ABSORB IRON etc.

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