Effectiveness of Antibody Isotypes Against Pathogens by Class and Location in th

Question

Effectiveness of Antibody Isotypes Against Pathogens by Class and Location in the Body

In this exercise, you will use information from the video presentations to deduce which antibody isotypes would be effective against various types of pathogens depending on their class (bacteria, viruses) and location in the body (on mucosal surfaces, in peripheral tissues, or in serum).

Antibodies act against extracellular pathogens, or against the extracellular forms of intracellular pathogens, such as viruses. Antibodies can also act against extracellular forms of bacterial exotoxins. If you need to review the properties of the relevant antibody isotypes again (IgM, IgG, IgA), you can do so by clicking here.

Use this information to deduce which antibody isotype(s) would be able to control infection by extracellular bacteria or viruses, or control disease caused by bacterial exotoxins, in serum, in tissues, or on mucosal surfaces. You can download a form on which to fill-in your answers by clicking here. [It is notnecessary to submit the completed form with your answer.]

Many pathogens do not establish disseminated infections.

What antibody isotype(s) would be effective for controlling infection by, or protecting against:

(1) pathogens that remain confined to the mucosal surface?

(2) pathogens that invade locally into tissues at, or near, the PoE, but do not disseminate?

(3) disease caused by a disseminated exotoxin produced by bacteria that remain localized at, or near, the PoE (systemic intoxication from localized infection)?

Explanation / Answer

1.IgA for mucosal surface are the isotype

2. IgM antibody for local invade

3. IgG for systemic intoxication

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