Could someone please show me how to do this problem? Please show all work/steps,

Question

Could someone please show me how to do this problem? Please show all work/steps, including the final answer(s). Thank you! A codon specifying Glycine undergoes a single-basesubstitution to become a nonsense mutation. (a) Is this mutation a transition or atransversion? (b) At which position of the codon does the mutationoccur? Could someone please show me how to do this problem? Please show all work/steps, including the final answer(s). Thank you! A codon specifying Glycine undergoes a single-basesubstitution to become a nonsense mutation. (a) Is this mutation a transition or atransversion? (b) At which position of the codon does the mutationoccur?

Explanation / Answer

The aminoacid Glycine is coded by 4 codons : GGU                                                                         GGC                                                                         GGA&                                                                         GGG   The asked question is Glycine undergoes single basesubstitution and becomes a nonsense mutation. So,among these 4 codons the codon which is more vulnerable tobecome a nonsense codon is GGA. When this codon's(GGA) first base is replaced by U then itbecomes a nonsense codon which is UGA, thereby causing a nonsensemutation. a)The type of mutation that occurred in this is atransversion because a purine base Guanine isreplaced by a     pyrimidine base Uracil. b)The mutation has occurred in the first position of thecodon ,G replaced byU.              

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