Could someone please show me how to do this problem? Please show all work/steps,

Question

Could someone please show me how to do this problem? Please show all work/steps, including the final answer(s). Thank you! In a haploid organism, a nine nucleotide segment of aprotein-coding gene encodes the amino acidsIsoleucine-Leucine-Isoleucine. Following exposure of theorganis to a mutagenic chemical, a researcher notes that the samesegment of the gene now encodes the amino acidsLysine-Tryptophan-Arginine. Assume all mutations thatoccurred were single-base substitutions. What was the DNAsequence of the codons present in the organism beforemutation? ___ ___ ___         ___ ___ ___          ___ ___ ___ Could someone please show me how to do this problem? Please show all work/steps, including the final answer(s). Thank you! In a haploid organism, a nine nucleotide segment of aprotein-coding gene encodes the amino acidsIsoleucine-Leucine-Isoleucine. Following exposure of theorganis to a mutagenic chemical, a researcher notes that the samesegment of the gene now encodes the amino acidsLysine-Tryptophan-Arginine. Assume all mutations thatoccurred were single-base substitutions. What was the DNAsequence of the codons present in the organism beforemutation? ___ ___ ___         ___ ___ ___          ___ ___ ___

Explanation / Answer

The original Sequence of the nine nucleotide segment can becalculated as follows: 1.The original sequence gave the amino acids: isoleucine-leucine-isoleucine 2.The mutated strain gave: lysine-tryptophan-arginine. So the single base substituitons are: AUA to AAA [isoleucine to lysine] UUG to UGG [leucine to tryptophan] CUC to CGC [isoleucine to arginine] So the original sequence of mRNA is: AUAUUGCUC The sequence of DNA is: ATATTGCTC.

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