Explain as simply as possible how you obtained your answer. 8. Hemophilia A and

Question

Explain as simply as possible how you obtained your answer.

8. Hemophilia A and B in Humans from X-linked recessive alleles. Hemophilia A, results in a deficiency of clotting factor VI, whereas Hemophilia B, h, results in a deficiency of clotting factor IX. A woman who is heterozygous /h and a normal male (h") produce a son whose chromosome constitution is XXY ha a. What is the name of this chromosome disorder? b. If the non-disjunction took place in meiosis I, what are the possible genotypes of their son with respect to hemophilia? 9. Examine the pedigrees below that represent sex-linked traits and respond to the following Give the most tikely mode of inheritance for each of the pedigrees. From pedigree A, give the probability that II-1 is heterozygous. a. Pedigrees: A. B. C. 10. Please provide two lines of evidence that lead scientist to believe that genes were located to chromosomes. Please write one complete sentence for each line of evidence and label your two sentences: "a" and "b.

Explanation / Answer

This condition calls as Klinefelter syndrome where one cell contains two extra X chromosomes. Generally, this syndrome comes through mother.

If nondisjuction took place, then the mother will produce two gametes of the following types-

44AA + XX

= 22A+ XX and 22A+ 0

Here the second cell not contains any gene of X chromosome. This cell will die. The other one that contains XX chromosome will make the Klinefelter syndrome.

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