a. Based on the pedigree, characterize each of the following modes of inheritanc
ID: 48547 • Letter: A
Question
a. Based on the pedigree, characterize each of the following modes of inheritance as likely, unlikely, or impossible: autosomal dominant, autosomal recessive, Y linked, X-linked dominant, and X-linked recessive. Justify your reasoning.
Further scrutiny of members of this family reveals the following: 1) The disease’s degree of expression varies among individuals, with some mildly affected, others moderately affected and still others severely affected; and 2) Individual III-14 was previously married. Her ex-husband is phenotypically normal, with no history of the disease in his family going back ten generations. He has custody of the couple’s two children, a girl and a boy, both of whom are affected with the disease. The partial pedigree is shown below (the “slash” represents separation or divorce)
b. Do these findings eliminate any of the remaining “likely or unlikely” modes of inheritance listed in part (a)? Are any of these modes of inheritance still possible? If so, which one(s) and why?
c. Is mitochondrial inheritance a likely, unlikely or an impossible mode of inheritance for this disease? Does it provide an explanation for the disease’s variable expressivity?
d. How can mitochondrial inheritance explain individual III-14?
Explanation / Answer
Answer 1a) Likely, unlikely and possible mode of inheritance is given below with explanation;
Answer 1b) No, these findings do not eliminate any of the remaining “likely or unlikely” modes of inheritance listed in part (a). there is still one mode of inheritance possible. it can likely be an Autosomal dominant trait, because it is not skipping the generation. also, it is possible that all the affected individuals are heterozygous, so their children may or may not be affected.
Answer 1c) Yes, mitochondrial inheritance is a likely mode of inheritance for this disease. in the case of mitochondi=rial inheritance, a disease carrying mitochondrial are passed on from mother to all of her children. it means that the disease trait is always passed on from affected mother to all of her offsprings. expect the individual III-14 which is giving birth to all of its affected offsprings but she is herself very mildly affected (significantly unaffected).
Answer 1d) Individual III-14 is herself very mildly affected (significantly unaffected) but giving birth to all of its affected offsprings. it also supports that it is likely mode of mitochondrial inheritance.
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