What is the fundamental difference between the initiation of replication and rol

Question

What is the fundamental difference between the initiation of replication and rolling-circle replication?    i) Essentially, one of the first things weneed to do in DNA replication is to provide a single strandedtemplate. In replication in E. coli, where does thisoccur?    ii)How many replication forks areproduced?    iii) What is the orientation of each?    iv) In rolling circle replication, how manyreplication forks are produced?    v) In comparison with i, where does thisoccur?    vi) What enzymatic/biochemical activity isnecessary to start the process? Does this occur in rolling circlereplication? What is the fundamental difference between the initiation of replication and rolling-circle replication?    i) Essentially, one of the first things weneed to do in DNA replication is to provide a single strandedtemplate. In replication in E. coli, where does thisoccur?    ii)How many replication forks areproduced?    iii) What is the orientation of each?    iv) In rolling circle replication, how manyreplication forks are produced?    v) In comparison with i, where does thisoccur?    vi) What enzymatic/biochemical activity isnecessary to start the process? Does this occur in rolling circlereplication?

Explanation / Answer

i. at ori site ii. 2 iii. bidirectional orientation iv. 1 on one strand and after this moves to other bacteria 1 forkon the other strand v. at the place of nick vi. normal replication occurs in model but in rolling circlethis replication partly resembles nick translation withoutstrand replacement

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